US 2024/0177869 A1 · METHOD AND SYSTEM FOR GENERATING A PLURALITY OF ANTIBODY SEQUENCES OF A TARGET FROM ONE OR MORE FRAMEWORK REGIONS

Abstract

A method and system for generating a plurality of antibody sequences of a target from one or more framework regions based on at least one model. The model is trained on a training dataset of high binding affinity to generate the complementarity determining regions (CDR) from the received one or more framework regions (FR). The generated complementarity determining regions (CDR) from the each of the one or more framework regions (FR) are combined with the associated one or more framework regions to generate one or more regions of the target. The generated one or more regions comprises each of the received one or more framework regions (FR) and corresponding each of the generated complementarity determining regions (CDR). The generated one or more regions are concatenated to generate the plurality of antibody sequences of the target. The generated plurality of antibody sequences of the target has high binding affinity.

Claims18

Dependent claims

A method for generating a plurality of antibody sequences of a target from one or more framework regions, comprising:

receiving one or more framework regions of one or more regions of an antibody sequence of the target, wherein the one or more regions of an antibody sequence comprises of one or more framework regions and one or more complementarity determining regions (CDR),
generating a plurality of complementarity determining regions (CDR) for each of the received one or more framework regions (FR), wherein the plurality of complementarity determining regions (CDR) is generated based on at least one model, and
combining the each of the received one or more framework regions (FR) and each of the generated complementarity determining regions (CDR) corresponding to each of the received one or more framework regions to generate one or more regions, and
concatenating the one or more regions to generate the plurality of antibody sequences of the target.

1 more element

A system for generating a plurality of antibody sequences of a target from one or more framework regions, comprising:

at least one server communicable coupled with at least one database, comprising of one or more processors configured to
receive one or more framework regions of one or more regions of an antibody sequence of the target, wherein the one or more regions of an antibody sequence comprises of one or more framework regions and one or more complementarity determining regions (CDR),
generate a plurality of complementarity determining regions (CDR) for each of the received one or more framework regions (FR), wherein the complementarity determining regions (CDR) is generated based on at least one model, and
combine the each of the received one or more framework regions (FR) and each of the generated complementarity determining regions (CDR) corresponding to each of the received one or more framework regions to generate one or more regions, and
concatenate the one or more regions to generate the plurality of antibody sequences of the target.

2 more elements

Dependencies are inferred from the claim text.

Method and system for generating a plurality of antibody sequences of a target from one or more framework regions

Life of this patent

Method and system for generating a plurality of antibody sequences of a target from one or more framework regions

Life of this patent

Abstract

Claims18