Method and system for generating a plurality of antibody sequences

Abstract

A method and system for generating a plurality of new antibody sequences corresponding to a target from a single lead antibody sequence. A model is pre-trained with a training dataset of plurality of known antibody sequences to learn a structural pattern from the plurality of known antibody sequences. The method includes receiving the single lead antibody sequence. The lead antibody sequence has one or more regions. The regions have one or more lead framework regions (FR) and one or more lead complementarity determining regions (CDR). The pre-trained model is configured to process the single lead antibody sequence to identify a relationship between the one or more lead framework regions (FR) and one or more lead complementarity determining regions (CDR). A plurality of new antibody sequences are generated from the single lead antibody amino acid of the sequence by the pre-trained model based on the identified relationship and the structural pattern.

Dependencies are inferred from the claim text.