Cellular diagnostic and analysis methods
AssigneeAquyre Biosciences, Inc.
InventorsBertrand LE CONTE CHRESTIEN DE POLY, Emilie BENOIT A LA GUILLAUME, Zoya I. VOLYNSKAYA
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Abstract
Detection of pathological abnormalities in tissue samples and/or pluralities of cells is a highly specialized and time-consuming effort, usually performed by a select group of clinicians and technical personnel. Described herein are methods for more automatable, consistent and comprehensive cell sample analysis to deliver a rapid, reliable and detailed classification, e.g., diagnosis, of the status of cells present in a sample, particularly, but not limited to cancer diagnosis.
Claims22
A method of determining the status of a plurality of cells, comprising:
- obtaining images of sub-cellular metabolic activity of a plurality of cells suspected to comprise a cancerous cell, wherein the images comprise time-dependent interferometric images;
- automatically assigning a status to at least a sub-set of the plurality of cells, wherein the status is selected from a normal cell status or a cancerous cell status;
- and
- assigning a cancer stage status to the sub-set of the plurality of cells.
A method of determining the effect of a molecule and/or biological agent upon a cell, comprising:
- obtaining images of sub-cellular metabolic activity of a plurality of cells, wherein the plurality of cells comprise at least one diseased cell and at least one non-diseased cell, wherein the images comprise time-dependent interferometric images;
- contacting the plurality of cells with a molecule and/or a biological agent;
- obtaining a plurality of images over a subsequent period of time, wherein the plurality of images comprises sub-cellular metabolic activity of the plurality of cells;
- and
- determining an effect of the molecule and/or the biological agent on the at least one diseased cell compared to an effect on the at least one non-diseased cell.
Dependencies are inferred from the claim text.