Methods and compositions for assessing and treating emetogenic drug-related nausea
AssigneeLankenau Institute for Medical Research
InventorMargaretha Wallon
Life of this patent
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Abstract
A method for assessing susceptibility to nausea of a patient comprises assessing the GSH recycling dependent antioxidant activity of the patient's blood cells prior to receiving an emetogenic agent. e.g., a cytostatic agent or a surgical anesthetic.
Claims1
A method for assessing susceptibility to nausea comprising assaying a biological sample containing red blood cells (RBC) for glutathione (GSH) recycling dependent antioxidant activity of the RBC as an indicator of oxidative stress, said sample obtained from a mammalian subject prior to administration of an emetogenic agent, wherein a high level of oxidative stress is predictive of increased susceptibility to nausea.
Dependencies are inferred from the claim text.