System and method for finding the peak wavelength of the spectrum sensed by an lspr spectrometer
AssigneeNicoya Lifesciences Inc.
InventorsUdayan KANADE, Sanat GANU
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Abstract
A system and method for finding the peak wavelength of the spectrum sensed by an LSPR spectrometer is described herein. The method comprises reading an image representing the reflected/absorbed spectrum, using a mathematical model of the LSPR spectrometer system to estimate a parametric curve representing the absorbance/reflectance spectrum, and adjusting or optimizing the parameters of the parametric curve so as to increase the likelihood of the parametric curve representing the sensed spectrum. Also described herein is a novel method to achieve LSPR peak wavelength signal noise reduction using an adaptive regularization algorithm.
Claims20
A method for finding a peak wavelength of a spectrum sensed by a spectrometer comprising:
- providing a sample comprising an analyte;
- analyzing the analyte using SPR analysis to produce a signal;
- using an imaging device to measure and store data from the signal, thereby yielding stored image data;
- and
- using a computer to:
- estimate from the stored image data a model spectrum representing an absorbance or reflectance spectrum;
- estimate from the model spectrum a mathematical modeling function comprising a parametric curve representing the absorbance/reflectance spectrum;
- and
- adjust parameters of the parametric curve thereby increasing the likelihood of the model spectrum representing the spectrum sensed by the spectrometer.
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Dependencies are inferred from the claim text.