Mutant herpesvirus and vaccine compositions
AssigneeRational Vaccines, Inc.
InventorsAgustin FERNANDEZ, Edward GERSHBURG, Paul PREDKI
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Abstract
Compositions and methods related to a mutant herpesvirus and a mutant ICP0 protein. Vaccine compositions comprising the mutant herpesvirus and/or mutant ICP0 protein. Methods of treatment using the mutant herpesvirus and/or mutant ICP0 protein.
Claims44
A mutant herpesvirus comprising a modified RL2 gene sequence, wherein the modified RL2 gene sequence encodes a polypeptide comprising one or more fragments of infected cell protein 0 (ICP0), wherein the polypeptide comprises or consists of, from the N-terminus to the C-terminus:
- a. a first ICP0 sequence comprising a sequence having at least 80% sequence identity to SEQ ID NO:
- 1 and comprising no more than 30 amino acids;
- b. optionally, a first non-ICP0 sequence;
- c. a second ICP0 sequence comprising a sequence having at least 80% sequence identity to SEQ ID NO:
- 2 and comprising no more than 30 amino acids;
- and,
- d. optionally, a second non-ICP0 sequence:
- wherein the first and second non-ICP0 sequences have less than 10% sequence identity to ICP0, and
- wherein the mutant herpesvirus is substantially avirulent and immunogenic.
A mutant ICP0 polypeptide comprising or consisting of, from the N-terminus to the C-terminus:
- a. a first ICP0 sequence comprising a sequence having at least 80% sequence identity to SEQ ID NO:
- 1 and comprising no more than 30 amino acids;
- b. optionally, a first non-ICP0 sequence;
- c. a second ICP0 sequence comprising a sequence having at least 80% sequence identity to SEQ ID NO:
- 2 and comprising no more than 30 amino acids;
- and
- d. optionally, a second non-ICP0 sequence:
- wherein the first and second non-ICP0 sequences have less than 10% sequence identity to ICP0.
Dependencies are inferred from the claim text.