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US 2024/0174979 A1Published application
Cartilage-derived progenitor cell lines
AssigneeRhode Island Hospital
InventorsQian CHEN, Chathuraka T. JAYASURIYA
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Abstract
This invention is directed to, inter alia, stable cartilage-derived progenitor cell lines as well as methods for producing stable cartilage-derived progenitor cell lines from diseased human cartilaginous tissues and lesions. Also provided herein are methods for using cartilage-derived progenitor cell lines for treatment of cartilage and bone degenerative diseases.
Claims31
A stable chondroprogenitor cell line that
- expresses less aggrecan (ACAN), type II collagen (COL2A1), SOX9, matrilin-3 (MATN3), and/or lubricin (PRG4) relative to chondrocytes derived from healthy adult tissue;
- or
- expresses less aggrecan (ACAN), type II collagen (COL2A1), SOX9, matrilin-3 (MATN3), and/or lubricin (PRG4) relative to chondrocytes derived from healthy adult tissue;
- or
- expresses less SOX9, aggrecan (ACAN), paired related homeobox 1 (PRX1) and/or Type X collagen relative to chondrocytes derived from healthy adult tissue.
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Dependencies are inferred from the claim text.