Methods for improving early embryo development
AssigneeShandong University
InventorsZijiang CHEN, Han ZHAO, Keliang WU, Honghui ZHANG
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Abstract
The general inventive concepts are based on the discovery that mammalian fertility and embryo development can be enhanced by a CHK1 inhibitor. A method for treating human infertility is disclosed. The method comprises identification of an individual having altered CHK1 function and administering a therapeutically effective amount of a CHK1 inhibitor. Further, embryonic development can be enhanced by the use of a culture medium comprising CHK1 inhibitor.
Claims21
A culture medium for mammalian embryo culturing, the culture medium comprising a therapeutically effective amount of a CHK1 inhibitor.
A method for enhancing embryonic development comprising:
- providing a culture medium, adding a therapeutically effective amount of a CHK1 inhibitor, and contacting the embryo with the culture medium.
A composition for reducing the risk of zygote arrest in an individual, the composition comprising a therapeutically effective amount of a CHK1 inhibitor.
A method for the treatment of infertility or altered kinase activity comprising, identifying an individual having altered CHK1 function, and administering therapeutically effective amount of a CHK1 inhibitor to the individual.
A method for the treatment and/or prevention of zygote arrest, the method comprises identifying a subject suffering from zygote arrest or at increased risk of zygote arrest, contacting a zygote from the individual with a therapeutically effective amount of a CHK1 inhibitor.
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Dependencies are inferred from the claim text.