Modular DNA Nanoshells for Cell Encapsulation and Ruggedization
AssigneeCarnegie Mellon University
InventorsRebecca Taylor, Weitao Wang, Xi Ren
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Abstract
Ruggedized particles or live cells are provided. The particles or cells comprise a cross-linked matrix of nucleic acid and/or nucleic acid analog nanostructures forming a shell about the particle or cell. Methods of making and using the ruggedized particles or live cells are provided. The ruggedized particles or cells may be decorated with environmental sensors, for example, which are prepared from nucleic acid and/or nucleic acid analog nanostructures and may include a FRET pair.
Claims20
A ruggedized particle or cell comprising:
- a particle or live cell;
- and
- a shell comprising a plurality of first nucleic acid and/or nucleic acid analog nanostructures anchored to the particle or cell;
- and a plurality of second nucleic acid and/or nucleic acid analog nanostructures cross-linking the plurality of first nucleic acid and/or nucleic acid analog nanostructures by a plurality of nucleic acid and/or nucleic acid analog staples.
A method of preparing a ruggedized particle or cell, comprising anchoring a plurality of first nucleic acid and/or nucleic acid analog nanostructures to a surface of a particle or a live cell, and forming a shell by crosslinking the plurality of first nucleic acid and/or nucleic acid analog nanostructures with a plurality of second nucleic acid and/or nucleic acid analog nanostructures using a plurality of nucleic acids and/or nucleic acid analog staples, wherein the plurality of first nucleic acid and/or nucleic acid analog nanostructures are attached to the plurality of second nucleic acid and/or nucleic acid analog nanostructures.
Dependencies are inferred from the claim text.