Swellable and Structurally Homogenous Hydrogels and Methods of Use Thereof
AssigneeMassachusetts Institute of Technology
InventorsRuixuan Gao, Linyi Gao, Chih-Chieh Yu, Edward Stuart Boyden
Life of this patent
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Abstract
The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
Claims41
A hydrogel that is the product of a non-radical polymerization reaction between a monomer of Formula (A1):
- and a monomer of Formula (B1):
- wherein
- each n is an integer greater than or equal to 1;
- each p is an integer greater than or equal to 1;
- Z+ is a counter cation;
- X and Y1 are each crosslinkable moieties, and
- X and Y1 covalently crosslink to end-link the monomers.
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5-8. (canceled)
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14-16. (canceled)
18-20. (canceled)
22-26. (canceled)
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31-36. (canceled)
38-40. (canceled)
A hydrogel that is the product of a non-radical polymerization reaction between a monomer of Formula (A2):
- and a monomer of Formula (B2)
- wherein:
- each n is an integer greater than or equal to 1;
- each q is an integer greater than or equal to 1;
- Y2 is a moiety comprising a terminal dibenzocyclooctyl (DBCO) or a terminal bicyclononyne;
- X1 is a moiety comprising a terminal azide group;
- Z is a counter cation;
- and
- X1 and Y2 crosslink by copper-free azide-alkyne cycloaddition.
42-45. (canceled)
47-49. (canceled)
51-55. (canceled)
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59-62. (canceled)
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A hydrogel that is the product of a non-radical polymerization reaction between a monomer of Formula (A5):
- and a monomer of Formula (B1):
- wherein:
- each n is an integer greater than or equal to 1;
- each p is an integer greater than or equal to 1;
- E is a moiety comprising a charged functional group;
- Z is a counter ion;
- X and Y1 are each crosslinkable moieties, and
- X and Y1 covalently crosslink to end-link the monomers.
67-69. (canceled)
A hydrogel that is the product of a non-radical polymerization reaction between a monomer of Formula (A6):
- and a monomer of Formula (B2)
- wherein:
- each n is an integer greater than or equal to 1;
- each q is an integer greater than or equal to 1;
- E is a moiety comprising a charged functional group;
- Z is a counter ion;
- Y2 is a moiety comprising a terminal dibenzocyclooctyl (DBCO) or a terminal bicyclononyne;
- X1 is a moiety comprising a terminal azide group;
- Z1 is a counter cation;
- and
- X and Y2 crosslink by copper-free azide-alkyne cycloaddition.
A monomer of Formula (A) selected from the group consisting of:
- wherein:
- each n is an integer greater than or equal to L;
- Z is a counter ion,
- Z+ is a counter cation;
- X is a crosslinkable moiety;
- X1 is a moiety comprising a terminal azide group;
- E is a moiety comprising a charged functional group.
(canceled)
A monomer of Formula (Bt) or Formula (B2):
- wherein:
- Y1 is a crosslinkable moiety;
- Y2 is a moiety comprising a terminal dibenzocyclooctyl (DBCO) or a terminal bicyclononyne;
- each p is an integer greater than or equal to 1;
- and
- each q is an integer greater than or equal to 1.
Dependencies are inferred from the claim text.