Back to results
US 2024/0174764 A1Published application
METHODS FOR TREATING GYNECOLOGIC CANCER USING COMBINATION THERAPY WITH ANTI-MUC16 x CD3 MULTISPECIFIC ANTIBODIES AND VEGF INHIBITORS
OwnerDavid Spriggs, Oladapo Yekuinventors
Life of this patent
Estimating the term…
Abstract
The present technology provides methods for treating gynecologic cancers using combination therapy with an anti-MUC16×CD3 multispecific (e.g., bispecific) immunoglobulin-related composition that specifically binds to the C-terminal 114 amino acid residues of mature MUC16 (e.g., MUC16C114) and T cells, and a VEGF inhibitor. Kits for use in practicing the methods are also provided.
Claims20
A method for treating gynecologic cancer in a subject in need thereof, comprising:
- administering to the subject an effective amount of an anti-MUC16×CD3 bispecific antibody or antigen binding fragment thereof, and an effective amount of a VEGF inhibitor, wherein the anti-MUC16×CD3 bispecific antibody or antigen binding fragment comprises a first antigen-binding site that specifically binds to a MUC16 polypeptide comprising an MUC16 ectodomain sequence, wherein the MUC16 ectodomain sequence consists of SEQ ID NO:
- 95.
Dependencies are inferred from the claim text.