Back to results
US 2024/0174751 A1Published application
Antibodies directed to claudin 6, including bispecific formats thereof
AssigneeIntegral Molecular, Inc.
InventorsJoseph RUCKER, Kyle DOOLAN
Life of this patent
Estimating the term…
Abstract
The disclosure is directed to an antibody specific for claudin 6 and CD3 and method of preparing and using the same. The present disclosure describes the isolation and characterization of antibodies, antibody fragments, and antibody variants specific for claudin 6 and CD3.
Claims28
-42. (canceled)
A bispecific antibody that binds to CLDN6 and CD3, the bispecific antibody comprising:
- a first polypeptide comprising a first light chain comprising a first variable light chain region, wherein the first variable light chain region comprises:
- (1) a CDR1 sequence comprising the amino acid sequence of SEQ ID NO:
- 1;
- (2) a CDR2 sequence comprising the amino acid sequence of SEQ ID NO:
- 2;
- and
- (3) a CDR3 sequence comprising the amino acid sequence of SEQ ID NO:
- 3;
- a second polypeptide comprising a first heavy chain comprising a first variable region heavy chain region, wherein the first variable heavy chain region comprises:
- (1) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4;
- (2) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and
- (3) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- and
- a third polypeptide comprising a second light chain and a second heavy chain, wherein:
- the second heavy chain comprises a second variable heavy chain region comprising:
- (1) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 25;
- (2) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 26;
- and
- (3) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 27;
- and
- the second light chain comprises a second variable light chain region comprising:
- (1) a CDR1 comprising the amino sequence of SEQ ID NO:
- 28;
- (2) a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 29;
- and
- (3) a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 30, or a variant thereof.
31 more elements
A bispecific antibody comprising:
- a first polypeptide comprising the amino acid sequence of SEQ ID NO:
- 67;
- a second polypeptide comprising the amino acid sequence of SEQ ID NO:
- 79;
- and
- a third polypeptide comprising the amino acid sequence of SEQ ID NO:
- 89.
4 more elements
Dependencies are inferred from the claim text.