Variable regions for nkp46 binding proteins
AssigneeInnate Pharma
InventorsLAURENT GAUTHIER, NADIA ANCERIZ, ARIANE MOREL, BENJAMIN ROSSI
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Abstract
The application pertains to NKp46-binding immunoglobulin variable regions, and proteins such as antibodies and multispecific proteins that comprise the variable regions. The proteins can bind and specifically redirect NK cells to lyse a target cell of interest. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
Claims9
A method of treating a disease in a subject comprising administering to the subject a composition comprising protein or polypeptide comprising an antigen binding domain that binds a human NKp46 polypeptide, wherein the domain comprises a heavy chain variable region (VH) and a light chain variable region (VL) combination selected from the group consisting of:
- (a) a VH comprising an amino acid sequence of SEQ ID NOS:
- 199 or 200 (NKp46-1 H1 or H3 variable domain), and a VL comprising an amino acid sequence of the amino acid sequence of SEQ ID NO:
- 201 (NKp46-1 L1 variable domain);
- (b) a VH comprising an amino acid sequence of SEQ ID NOS:
- 202, 203 or 204 (NKp46-2 H1, H2 or H3 variable domain), and a VL comprising an amino acid sequence of SEQ ID NO:
- 205 (NKp46-2 L1 variable domain);
- (c) a VH comprising an amino acid sequence of SEQ ID NOS:
- 206, 207 or 208 (NKp46-3 H1, H3 or H4 variable domain), and a VL comprising an amino acid sequence of SEQ ID NO:
- 209 (NKp46-3 L1 variable domain);
- (d) a VH comprising an amino acid sequence of SEQ ID NOS:
- 210, 211 or 212 (NKp46-4 H1 variable domain), and a VL comprising an amino acid sequence of SEQ ID NO:
- 213 (NKp46-4 L2 variable domain);
- (e) a VH comprising an amino acid sequence of SEQ ID NO:
- 215 (NKp46-9 H2 variable domain), and a VL comprising an amino acid sequence of SEQ ID NOS:
- 217 or 218 (NKp46-9 L1 or L2 variable domain);
- or
- (f) a VH comprising an amino acid sequence of SEQ ID NO:
- 216 (NKp46-9 H3 variable domain), and a VL comprising an amino acid sequence of SEQ ID NOS:
- 217 or 218 (NKp46-9 L1 or L2 variable domain).
A multispecific antigen binding protein, a protein, or polypeptide comprising an antigen binding domain that binds a human NKp46 polypeptide, wherein the domain comprises a heavy chain variable region (VH) and a light chain variable region (VL) combination selected from the group consisting of:
- (a) a VH comprising an amino acid sequence of SEQ ID NOS:
- 199 or 200 (NKp46-1 H1 or H3 variable domain), and a VL comprising an amino acid sequence of the amino acid sequence of SEQ ID NO:
- 201 (NKp46-1 L1 variable domain);
- (b) a VH comprising an amino acid sequence of SEQ ID NOS:
- 202, 203 or 204 (NKp46-2 H1, H2 or H3 variable domain), and a VL comprising an amino acid sequence of SEQ ID NO:
- 205 (NKp46-2 L1 variable domain);
- (c) a VH comprising an amino acid sequence of SEQ ID NOS:
- 206, 207 or 208 (NKp46-3 H1, H3 or H4 variable domain), and a VL comprising an amino acid sequence of SEQ ID NO:
- 209 (NKp46-3 L1 variable domain);
- (d) a VH comprising an amino acid sequence of SEQ ID NOS:
- 210, 211 or 212 (NKp46-4 H1 variable domain), and a VL comprising an amino acid sequence of SEQ ID NO:
- 213 (NKp46-4 L2 variable domain);
- (e) a VH comprising an amino acid sequence of SEQ ID NO:
- 215 (NKp46-9 H2 variable domain), and a VL comprising an amino acid sequence of SEQ ID NOS:
- 217 or 218 (NKp46-9 L1 or L2 variable domain);
- or
- (f) a VH comprising an amino acid sequence of SEQ ID NO:
- 216 (NKp46-9 H3 variable domain), and a VL comprising an amino acid sequence of SEQ ID NOS:
- 217 or 218 (NKp46-9 L1 or L2 variable domain).
Dependencies are inferred from the claim text.