Antigen-binding protein targeting pneumolysin and use thereof
AssigneesStarmab Biologics (suzhou) Co., Ltd., Starmab Biologics (Shanghai) Co., Ltd
InventorsMaomao An, Shiyu Guo, Simin Chen, Xiran Qiu, Bohua Li
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Abstract
Provided is an isolated antigen-binding protein, which comprises at least one CDR in an antibody heavy chain variable region VH, wherein the VH comprises the amino acid sequence as shown in SEQ ID NO: 39. The isolated antigen-binding protein can specifically bind to pneumolysin protein and variants thereof. Further provided is the use of the isolated antigen-binding protein in prevention and/or treatment of diseases and/or conditions of a Streptococcus pneumoniae infection.
Claims68
An isolated antigen-binding protein comprising at least one CDR of the heavy chain variable region VH of an antibody, the VH comprising the amino acid sequence shown in SEQ ID NO:
- 39.
Dependencies are inferred from the claim text.