A use of a polypeptide compound in the preparation of drugs for preventing or treating inflammatory bowel diseases and related intestinal fibrosis

Abstract

The present invention discloses a use of a polypeptide compound in the preparation of drugs for preventing or treating inflammatory bowel diseases and related intestinal fibrosis, wherein the polypeptide compound comprises a parent peptide represented by the following amino acid sequence: His-Xaa2-Gln-Gly-Thr5-Phe-Thr-Ser-Asp-Lys10-Ser-Lys-Tyr-Leu-Xaa1515-Xaa16-Xaa17-Ala-Ala-Gln20-Xaa21-Phe-Xaa23-Xaa24-Trp25-Leu-Xaa27-Xaa28-Gly-Gly30-Pro-Ser-Ser-Gly-Xaa3535-Pro-Pro-Pro-Ser. The polypeptide compound can not only reduce serum inflammatory factors, inhibit neutrophil infiltration and alleviate inflammation levels; and the polypeptide compound can also reduce pro-fibrotic factors and downregulate protein expressions of α-SMA and Fibronectin and have significant therapeutic effect on inflammatory bowel disease and related intestinal fibrosis.

Dependencies are inferred from the claim text.