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US 2024/0174727 A1Published application
Long-acting natriuretic peptides and uses thereof
OwnerJorge ALSINA-FERNANDEZ, Hana Elisabeth BAKER +8inventors
InventorsJorge ALSINA-FERNANDEZ, Hana Elisabeth BAKER, Guillermo S. CORTEZ, Michael Lawrence ELMUCCIO, Wen LIU, Daniel Christopher LOPES, Avinash MUPPIDI, Francisco Alcides VALENZUELA, Yan WANG, Lin ZHANG
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Abstract
The present invention relates to Atrial Natriuretic Peptide (ANP) polypeptides and methods of treatment with ANP polypeptides.
Claims19
A polypeptide comprising:
- (SEQ ID NO:
- 3)
- X1X2X3RSSCFX9X10X11IX13RIGX17X18SGLGCPSX26RX28X29,
- wherein:
- X1 is absent, S or E,
- X2 is absent, L, K, 4-Pal, H or E,
- X3 is absent, R, β-Ala, P, K, E or G,
- X9 is G, 4-Pal or H,
- X10 is G, K, R, or Dap,
- X11 is R, K, G or Dap,
- X13 is D or G,
- X17 is A, H, Dap, K, R or Orn,
- X18 is Q, Y or 4-Pal,
- X26 is F or L,
- X28 is Y, H or 4-Pal and
- X29 is either absent or selected from
- GGP,
- (SEQ ID NO:
- 4)
- SGAPPPE,
- (SEQ ID NO:
- 5)
- KITAKEDE,
- (SEQ ID NO:
- 6)
- GPSSGAPPPE,
- (SEQ ID NO:
- 7)
- GPSSGAPPPS,
- (SEQ ID NO:
- 8)
- GGSSGAPPPS,
- (SEQ ID NO:
- 9)
- GGPSSGAPPPS,
- (SEQ ID NO:
- 10)
- KGPSSGAPPPS,
- (SEQ ID NO:
- 11)
- GGKSSGAPPPS,
- (SEQ ID NO:
- 12)
- GGPPS-Aib-KPPPK,
- (SEQ ID NO:
- 13)
- GSPSSGAPPPS,
- (SEQ ID NO:
- 14)
- RITAREDKQGYA,
- (SEQ ID NO:
- 15)
- RITAREDKQGEA,
- (SEQ ID NO:
- 16)
- GSPSSGAPPPS-PEG24-G,
- (SEQ ID NO:
- 17)
- SGSPSSGAPPPSG,
- (SEQ ID NO:
- 18)
- GGESSGEPPPSEE,
- (SEQ ID NO:
- 19)
- GSGSPSSGAPPPSG,
- and
- (SEQ ID NO:
- 20)
- SGSPSSGAPPPSEEEG
- and the C-terminal amino acid is optionally amidated.
- or a pharmaceutically acceptable salt thereof.
68 more elements
19-25. (canceled)
Dependencies are inferred from the claim text.