Hepcidin analogues and uses thereof
AssigneeProtagonist Therapeutics, Inc.
InventorsMark Leslie SMYTHE, Gregory Thomas BOURNE, Simone VINK, Brian Troy FREDERICK, Praveen MADALA, Anne Pernille TOFTENG SHELTON, Jacob Ulrik FOG
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Abstract
The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.
Claims15
1-30. (canceled)
A method of treating a disease of iron metabolism in a subject in need thereof comprising administering to said subject a peptide comprising the following sequence:
- (SEQ ID NO:
- 241)
- Isovaleric acid-DTHFPCI(K(isoGlu-Palm))FEPRSKGCK-
- NH2
- or a pharmaceutically acceptable salt thereof,
- wherein the peptide of SEQ ID NO:
- 241 comprises a disulfide bond between two cysteine residues.
Dependencies are inferred from the claim text.