Ryanodine receptor inhibitor compounds and methods relating thereto
OwnerJeffrey N. Johnston, Suzanne Batiste +3inventors
InventorsJeffrey N. Johnston, Suzanne Batiste, Abigail N. Smith, Daniel J. Blackwell, Björn C. Knollmann
Life of this patent
Estimating the term…
Abstract
Anodine receptor type 2 (RyR2) inhibitors and methods of their use in the treatment of cardiac conditions.
Claims16
A compound of the following formula:
- wherein each R1 is independent and chosen from C1-C12 substituted or unsubstituted alkyl;
- and pharmaceutically acceptable salts thereof.
A method of treating a subject suffering from a cardiac condition associated with RyR2, comprising administering to a subject in need thereof a RyR2 inhibiting effective amount of a compound of the following formula:
- wherein each R1 is independent and chosen from C1-C12 substituted or unsubstituted alkyl;
- and pharmaceutically acceptable salts thereof.
A method of treating a subject suffering from a cardiac condition associated with RyR2, comprising the step of co-administering to a subject in need thereof a RyR2 inhibiting effective amount of a compound of the following formula:
- wherein each R1 is independent and chosen from C1-C12 substituted or unsubstituted alkyl;
- and pharmaceutically acceptable salts thereof;
- with a drug having a known effect of treating a cardiac condition.
Dependencies are inferred from the claim text.