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US 2024/0174713 A1Published application
Peptide synthesis method involving sterically hindered mixed anhydride intermediate
AssigneeAmicoat AS
InventorsJacobus Johannes Eksteen, John Sigurd Svendsen, Sophie Borghese, Florence Malmedy, Martin Bousmanne
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Abstract
The invention is directed to a method of making a target peptide comprising reacting a mixed anhydride compound of Formula (I) with a second moiety which is an amino acid or peptide, wherein Formula (I) has the following structure: and wherein R1-R3 are as defined in the disclosure.
Claims22
A method for making a target peptide comprising reacting a mixed anhydride compound of Formula (I) with a second moiety which is an amino acid or peptide;
- wherein Formula (I) has the structure:
- wherein R1 is a protecting group, a peptide or an amino acid;
- wherein R2 is tent-butyl, isobutoxy, tert-butoxy, isobutyl, isopropoxy, isopropyl, or ethoxy;
- and
- wherein R3 is H or an alkylsilyl group.
2 more elements
(canceled)
18-21. (canceled)
Dependencies are inferred from the claim text.