Somatostatin receptor subtype 4 (sstr4) agonists and their applications

A compound of Formula (I), or stereoisomer, pharmaceutically acceptable salt, solvate, deuterate, metabolite, or prodrug thereof;

• wherein
• R1 and R2 are independently selected from H, deuterium, C1-C6 alkyl, substituted C1-C6 alkyl, C3-C6 cycloalkyl, C4-C9 alkylcycloalkyl, C2-C6 alkenyl, substituted C2-C6 alkenyl, aryl, substituted aryl, alkylaryl, or substituted alkylaryl;
• wherein the substituted C1-C6 alkyl, substituted C3-C6 cycloalkyl, and substituted aryl are substituted with 1-3 substituents independently selected from the following groups:
• C1-C3 alkyl, C1-C3 alkoxy, halogen, or halogenated C1-C3 alkyl;
• or
• R1 and R2 are connected to form three-member, four-member, five-member and six-member rings;
• A is selected from the following
• wherein
• n=1, 2, 3, 4;
• m=1, 2, 3, 4;
• R3 is selected from the group consisting of H, deuterium, C1-C6 alkyl, oxygen-containing alkyl, and nitrogen-containing alkyl;
• B is selected from the group consisting of aromatic ring, substituted aromatic ring, heterocycle, substituted heterocycle, alkyl heterocycle, and substituted alkyl heterocycle;
• wherein the substituted heterocycle or alkyl heterocycle is substituted by 1-3 independently selected from the group consisting of deuterium, halogen, cyano, C1-C6 alkyl, halogenated C1-C6 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, alkylsilyl, aryl, substituted aryl, or oxygen, sulfur, selenium-containing alkyl.