Pyrimidine aromatic ring compounds

A compound represented by formula (II), or a pharmaceutically acceptable salt thereof

• wherein
• E1 is selected from S and —CR3═CH—;
• L1 is selected from —CH2— and a bond;
• Ring A is selected from
• wherein the
• are optionally substituted with 1, 2 or 3 Ra;
• T1 is selected from CH2, NH and O;
• T2 is selected from CH and N;
• T3 and T4 are each independently selected from CH2 and NH;
• m, n, p and x are each independently selected from 0, 1 and 2;
• r, v and w are each independently selected from 1 and 2;
• q, s and u are each independently selected from 1, 2 and 3;
• R1 is selected from C6-10 aryl and 5- to 10-membered heteroaryl, wherein the C6-10 aryl and 5- to 10-membered heteroaryl are optionally substituted with 1, 2, 3, 4 or 5 Rb;
• R2 is selected from H, F, Cl, CN, NH2, C1-3 alkyl and C1-3 alkoxy, wherein the C1-3 alkyl and C1-3 alkoxy are optionally substituted with 1, 2 or 3 halogens;
• R3 is selected from H, F, Cl, C1-3 alkyl, C1-3 alkoxy, C2-4 alkenyl and cyclopropyl, wherein the C1-3 alkyl, C1-3 alkoxy, C2-4 alkenyl and cyclopropyl are optionally substituted with 1, 2 or 3 halogens;
• R4 is selected from 4- to 8-membered heterocycloalkyl and
• wherein the 4- to 8-membered heterocycloalkyl and
• are optionally substituted with 1, 2 or 3 Re;
• the structural moiety
• is 5- to 6-membered heterocycloalkenyl;
• each Ra is independently selected from F, Cl, Br, I and CH3;
• each Rb is independently selected from F, Cl, Br, I, OH, NH2, CN, C1-3 alkyl, C1-3 alkoxy, C2-4 alkenyl and C2-4 alkynyl, wherein the C1-3 alkyl, C1-3 alkoxy, C2-4 alkenyl and C2-4 alkynyl are optionally substituted with 1, 2 or 3 halogens;
• each Re is independently selected from H, F, Cl, Br, OH, CN, C1-3 alkyl, C1-3 alkoxy and —C1-3 alkyl-O—C(═O)—C1-3 alkylamino.