Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof

A compound having a structural Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• A is a heteroaryl or aryl selected from the group consisting of thiazolyl, pyrazolyl, pyridyl, phenyl, pyrimidinyl, oxazolyl and pyrazinyl;
• R1 is selected from hydrogen, C1-6 alkyl, —(CH2)nOC1-6 alkyl, —(CH2)nhalogen, —(CH2)nCN, C1-6 haloalkyl, —CH(R)2, —(CH2)nC3-6cycloalkyl, —(CH2)nC6-10aryl, —(CH2)nC5-10heteroaryl, —(CH2)nC4-10heterocyclyl, and —(CH2)nN(R)2, said alkyl and cycloalkyl, aryl, heteroaryl, and heterocyclyl optionally substituted with 1 to 3 groups selected from Rx;
• R is selected from hydrogen, C1-6 alkyl, cyclopropyl, CN, NHCH(CH3)2, and phenyl, said phenyl optionally substituted with 1 to 3 groups of Rx;
• R2 is selected from hydrogen, C1-6 alkyl, —OC1-6 alkyl, halogen, C(O)C1-6alkyl, C(O)N(R)2, —C(O)OC1-6alkyl, CN, C1-6haloalkyl, —C3-6cycloalkyl, (O)0-1C6-10aryl, C5-10heteroaryl, and —(CH2)nN(R)2, said alkyl and cycloalkyl, aryl, and heteroaryl optionally substituted with 1 to 3 groups selected from Rx;
• Ra is selected from C1-6 alkyl, CN and halogen;
• Rb are independently selected from C1-6 alkyl, —OC1-6 alkyl, C3-6 cycloalkyl, —SC1-6alkyl, C6-10 aryl, C5-10heteroaryl, C3-10heterocyclyl, NHC(O)C1-6alkyl, N(R)2, and —NHC6-10aryl, said alkyl, aryl, heteroaryl, and heterocyclyl optionally substituted with 1 to 3 groups of Ry;
• Rx is selected from C1-6 alkyl, —OC1-6 alkyl, OH, C3-6 cycloalkyl —CH2SC1-6 alkyl, —OCH2OC1-6 alkyl, halogen, —SO2CH3, CN, and (CH2)nN(R)2,
• Ry is selected from hydrogen, C1-6 alkyl, —(CH2)nOC1-6 alkyl, C3-6cycloalkyl, C1-6 haloalkyl, -halogen, CN, (CH2)nC4-10heterocyclyl, —(CH2)n 5-10heteroaryl, and —SO2C1-6 alkyl;
• and
• n is selected from 0 to 3.