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US 2024/0174673 A1Published application
Spirocycle Containing Pyridine Compounds
AssigneeProtego Biopharma, Inc.
InventorsHuang Qiu, Steven J. Wilkens, Hank Michael James Petrassi, Richard F. Labaudiniere, Bo Qin
Life of this patent
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Abstract
Provided herein are compounds that stabilize immunoglobulin light chains, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with light chain amyloidosis.
Claims106
A compound of Formula I:
- or a pharmaceutically acceptable derivative thereof, wherein
- n is an integer from 1-4;
- p is an integer from 1-3;
- m, s and t are each independently an integer from 0-3;
- X1 is a bond, O, NR16 or CO;
- X2 is a bond, CONR17, SO2NR17, CO or SO2;
- X3 is a bond, CONR18, SO2NR18, CO or SO2;
- R1 is aryl, heteroaryl or heterocycloalkyl;
- R2 is H, COR19, COOR19, CONR19R20, aryl or heteroaryl;
- R3 to R6, R9 to R14, and R16 to R20 are each independently H, alkyl or aralkyl;
- R7 and R8 are each independently H, alkyl or aralkyl, or together with the carbon atom to which they are attached form cycloalkyl;
- and
- R15 is H, alkyl, aralkyl, halo or haloalkyl.
10 more elements
A compound of Formula II:
- or a pharmaceutically acceptable derivative thereof, wherein:
- b is an integer from 1-4;
- c is an integer from 1-3;
- a, d and f are each independently an integer from 0-3;
- X11 is a bond, O, NR36 or CO;
- X12 is a bond, CONR37, SO2NR37, CO or SO2;
- X13 is a bond, CONR38, SO2NR38, CO or SO2;
- R21 is aryl, heteroaryl or heterocycloalkyl;
- R22 is H, COR39, COOR39, CONR39R40, aryl or heteroaryl;
- R23, R24, R29 to R34, and R36 to R40 are each independently H, alkyl or aralkyl;
- R27 and R28 are each independently H, alkyl or aralkyl, or together with the carbon atom to which they are attached form cycloalkyl;
- and
- R35 is H, alkyl, aralkyl, halo or haloalkyl.
10 more elements
Dependencies are inferred from the claim text.