US 2024/0174660 A1 · KRAS G12C INHIBITORS AND METHODS OF USING THE SAME

Kras g12c inhibitors and methods of using the same

AssigneeAmgen Inc.

InventorsBrian Alan LANMAN, Jian CHEN, Anthony B. REED, Victor J. CEE, Longbin LIU, David John KOPECKY, Patricia LOPEZ, Ryan Paul WURZ, Thomas T. NGUYEN, Shon BOOKER, Nobuko NISHIMURA, Youngsook SHIN, Nuria A. TAMAYO, John Gordon ALLEN, Jennifer Rebecca ALLEN

Life of this patent

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Abstract

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Claims14

Dependent claims

A compound, wherein the compound is selected from:

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

18/543,498Filed 18 Dec 2023

Priority

22 May 2017

Published

30 May 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification29 codes

C07D 417/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61K 31/416
1,2-Diazoles: condensed with carbocyclic ring systems, e.g. indazole
A61K 31/454
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/496
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: non-condensed piperazines…

Family

Application62/509,629Us provisional application · filed 22 May 2017

Application15/984,855Continuation · filed 21 May 2018

Application16/661,907Continuation · filed 23 Oct 2019

Application17/031,607Continuation · filed 24 Sep 2020

Application18/543,498Continuation

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US 2018/0334454 A1Published application

US 2020/0055845 A1Published application

US 2021/0009577 A1Published application

US 2024/0174660 A1This patent

From the US filing history. Foreign family members aren’t listed.