Quinoxaline urea inhibitors of ikk-beta and nf-kb
AssigneeBoard of Regents of the University of Nebraska
InventorAmarnath Natarajan
Life of this patent
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Abstract
Provided herein are compounds having a structure of Formula I, Formula II, or Table 1 as disclosed herein and methods of using the disclosed compounds to inhibit IKKI3 activity. For example, the compounds of Formula I, Formula II, and Table 1 as disclosed herein are useful for methods of treating diseases and disorders including, without limitation, cancer.
Claims55
A compound, or pharmaceutically acceptable salt thereof, having the structure of Formula I:
- wherein
- X and Y are each independently N or CH;
- Z is 0, S, NRM, or CH2;
- RM and RN are each independently H or C1-3 alkyl;
- R1 and R2 are each independently H or 5-7 membered heteroaryl having 1-4 ring heteroatoms selected from O, S, and N, wherein the heteroaryl is optionally substituted with 1-4 R6;
- R3, R4, and R5 are each independently H, halogen, C1-6 alkyl optionally substituted with 1-3 R7, C1-6 alkoxy, C2-6 haloalkoxy, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl, C2-6 haloalkynyl, C6 aryl optionally substituted with 1 -3 R7, or 5-7 membered heteroaryl having 1-4 ring heteroatoms selected from O, S, and N;
- R6 is halogen, C1-6 alkyl optionally substituted with 1-3 R7, C2-6 alkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl, C2-6 haloalkynyl, or C2-6 aryl optionally substituted with 1 -3 R7;
- and
- R7 is halogen, OH,CN, C1-6 alkyl optionally substituted with 1 -3 halogen, C1-6 alkoxy, CO2H, or CO2C2-6 alkyl, with the proviso that
- (i) one of X and Y is CH, or
- (ii) Z is CH2, or
- (iii) R5 is not H.
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A compound, as recited in Table 1, or a pharmaceutically acceptable salt thereof:
- TABLE 1
- Compound
- No.
- Structure
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
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Dependencies are inferred from the claim text.