Heterocyclic compounds capable of activating sting

A compound of formula (I)

• wherein
• B is a group selected from among the group consisting of
• a 5-7-membered monocyclic heterocyclyl containing 1 or 2 N-atoms,
• a 6-membered bicyclic heterocyclyl containing 1 N-atom,
• a 7-11 membered bicyclic heterocyclyl containing 1 or 2 N-atoms,
• a 7-membered bicyclic heterocyclyl containing 1 N-atom and 1 O-atom,
• a 6-membered monocyclic heterocyclyl containing 1 N-atom and 1 heteroatom selected from among the group consisting of O and S,
• a 9-membered bicyclic heterocyclyl containing 3 heteroatoms, 2 of which are N and the other is 0,
• a 9-membered bicyclic heterocyclyl containing 1 N-atom and 1 S-atom,
• a 10-membered bicyclic heterocyclyl containing 3 N-atoms, 2 of which are substituted with C1-6-alkyl,
• phenyl,
• a 9-membered bicyclic heteroaryl containing 3 N-atoms,
• —C1-4-alkylene-pyrimidine, and
• —C1-4-alkylene-O—C1-3-alkyl;
• D is a group selected from among the group consisting of
• a 9-membered bicyclic heteroaryl containing 2 N-atoms,
• a 10-membered bicyclic heteroaryl containing 1 N-atom, and benzodioxole;
• R1 is selected from among the group consisting of —H or —C1-6-alkyl;
• R2 is selected from among the group consisting of —H, halogen, preferably fluorine or chlorine, more preferably fluorine, and —C1-6-alkyl;
• R3 is selected from among the group consisting of —H, halogen, preferably fluorine or chlorine, more preferably fluorine, and —C1-6-alkyl;
• R4a, R4b and R4c are each independently selected from —H, halogen, preferably fluorine or chlorine, more preferably fluorine, and C1-6-alkyl, with the proviso that at least one of R4a, R4b and R4c is halogen;
• R4d is selected from —C1-6-alkyl and C3-6 cycloalkyl;
• R5 is absent or is selected from among the group consisting of —H, —C1-6-alkyl, —S(O2)—C1-6-alkyl, —NH—S(O2)—C1-6-alkyl, ═O, —C(O)—C1-6-alkyl, —C(O)H, —C(O)OH, —C(O)NH2, —C(O)O—C1-6-alkyl, —NR5.1R5.2, —C1-6-alkylene-C(O)OH, —S(O2)—NH2, -pyrolidin-2-one-1-yl, -tetrazolyl, and a 5-membered heteroaryl with 1 or 2 heteroatoms selected from among the group consisting of N and O which is substituted with R5.3;
• R5.1 is selected from among the group consisting of —H, —C1-6-alkyl, —C(O)—C1-6-alkyl and —C1-6-alkylene-O—C1-6-alkyl;
• R5.2 is selected from among the group consisting of —H, —C1-6-alkyl, —C(O)—C1-6-alkyl and —C1-6-alkylene-O—C1-6-alkyl;
• R5.3 is selected from among the group consisting of —H, —C1-6-alkyl and a 6-membered heteroaryl with 1 or 2 heteroatoms selected from a group consisting of N and O;
• R6 is absent or is selected from among the group consisting of —H, —C1-6-alkyl, ═O and —C(O)OH;
• or a pharmaceutically acceptable salt thereof.