Compounds and methods for cd73 modulation and indications therefor

A compound having the following formulae:

• or a pharmaceutically acceptable salt thereof, wherein
• R2 is Cl, Br, CF3, or CN;
• and
• G is heteroaryl substituted with 0-3 T5 and 0-1 T3;
• T3 is —(CH2)0-3—C(O)N(R8)R9, —(CH2)0-3—N(R8)R9, —(CH2)0-3—C(O)OR9, —(CH2)0-3-cycloalkyl, —(CH2)0-3-cycloalkenyl, —(CH2)0-3-heterocycloalkyl, —(CH2)0-3-heterocycloalkenyl, —O-heterocycloalkyl optionally substituted with 4-chloropyridazin-3-one-5-yl, or —(CH2)0-3-bridged carbocyclic ring, wherein the —(CH2)0-3-cycloalkyl, —(CH2)0-3-cycloalkenyl, —(CH2)0-3-heterocycloalkyl, —(CH2)0-3-heterocycloalkenyl, or —(CH2)0-3-bridged carbocyclic are each optionally substituted with 1-3 Z5 and 0-1 Z1, provided that when T3 is attached to a heteroatom of G, G cannot be attached to an oxygen or nitrogen atom of T3;
• each T5 is independently halogen, hydroxyl, alkyl optionally substituted with 1-3 Rb, alkenyl optionally substituted with 1-3 Rb, alkynyl optionally substituted with 1-3 Rb, CN, cyanoalkyl, alkoxyl optionally substituted with 1-3 Rb, or alkoxyalkyl optionally substituted with 1-3 Rb, provided that when T5 is attached to a heteroatom of G, T5 cannot be halogen, hydroxyl, CN, or alkoxyl optionally substituted with 1-3 Rb;
• R8 is H, alkyl optionally substituted with 1-4 Z4, alkenyl optionally substituted with 1-4 Z4, —C0-C3alkyl-cycloalkyl optionally substituted with 1-4 Z3, —C0-C3alkyl-phenyl optionally substituted with 1-4 Z3, —C0-C3alkyl-heteroaryl optionally substituted with 1-3 Z5, —C0-C3alkyl-heterocycloalkyl optionally substituted with 1-3 Z5, or a bridged carbocylic ring substituted with 0-5 T;
• each R9 is independently H or alkyl optionally substituted with 1-4 Z4;
• each T1 is independently halogen, hydroxyl, alkyl optionally substituted with 1-3 Rb, alkenyl optionally substituted with 1-3 Rb, alkynyl optionally substituted with 1-3 Rb, CN, cyanoalkyl, alkoxyl optionally substituted with 1-3 Rb, or alkoxyalkyl optionally substituted with 1-3 Rb;
• Rb is halogen, CN, CF3, or hydroxyl, provided that not more than 1 Rb can be CF3;
• each Z3 is independently alkyl, halogen, haloalkyl, hydroxyl, hydroxyalkyl, alkoxyl, alkoxyalkyl, or CN;
• each Z4 is independently hydroxyl, halogen, alkoxyl, or CN;
• and
• each Z5 is independently alkyl, haloalkyl, hydroxyl, hydroxyalkyl, halogen, alkoxyl, alkoxyalkyl, CN, or cyanoalkyl, provided that when Z5 is attached to a heteroatom, then Z5 is not halogen, hydroxyl, alkoxyl, or CN.