2-acetamido-6-hydroxy-benzothiophene derivatives with antiviral activity
AssigneeOtcpharm Jsc
InventorsVadim Albertovich MAKAROV, Vladimir Viktorovich ZARUBAEV
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Abstract
The invention relates to a novel derivative of 2-acetamido-6-hydroxy-benzothiophene of general formula I, or a pharmaceutically acceptable salt thereof, which has antiviral activity and can be used for treating viral diseases caused by respiratory RNA viruses, influenza viruses or coronaviruses. The primary use of the claimed compounds is for treating diseases where the virus is an influenza virus or the coronavirus SARS-CoV-2 and the disease is influenza A or COVID-19.
Claims16
A 2-acetamido-6-hydroxy-benzothiophene derivative of general structural formula I or a pharmaceutically acceptable salt thereof
- where
- R1 is CN, COOH, COOAlk, CONHAlk, CON(Alk)2, CONH2;
- R2 is H, Hal, CH2(NAlk)2;
- R3 is Hal, Alk, OAlk, CF3, or two adjacent R3 groups form —CH═CH—CH═CH-group;
- R4 is H or Hal;
- n=1-4;
- m=1-3;
- X is hydrogen or methyl;
- Hal is fluorine, chlorine or bromine;
- Alk is a linear or branched alkyl group having 1 to 4 carbon atoms, or
- in N(Alk)2 group, two Alk groups together with the nitrogen atom to which they are attached form a —(CH2)p group, wherein p=3-5, in which one of said CH2 groups can be substituted by a nitrogen or oxygen atom, or by a —N—CH3 group.
Dependencies are inferred from the claim text.