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US 2024/0174625 A1Published application
Compositions and methods for treating tauopathies
AssigneeThe Regents of the University of California
InventorsDaniel H. Geschwind, Michael E. Jung, Liting Deng, Flora Hinz, Jennifer M. Murphy, Gaoyuan Ma, Robert Damoiseaux
Life of this patent
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Abstract
Disclosed are compounds and methods for treating tauopathy.
Claims52
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is C(R0)2, NR1, O or S;
- ring A is C6-10 aryl or 5- to 10-membered heteroaryl;
- ring B is C6-14 aryl or 5- to 10-membered heteroaryl;
- R0 is halogen, amino, hydroxyl, alkoxy, cyano, nitro, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- R1 is hydrogen, sulfonyl, alkyl, aralkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- R2 and R3 independently are hydrogen, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- or
- R2, R3, and the carbon atom to which they are connected, complete an oxo group (C═O);
- or
- R3, ring B, and the intervening atoms, complete a carbocyclyl, heterocyclyl, aryl, or heteroaryl;
- m is 0, 1, or 2, preferably 1, and
- provided the compound is not
10 more elements
Dependencies are inferred from the claim text.