Back to results
US 2024/0174615 A1Published application
Synthesis of rapamycin analog compounds
AssigneeRevolution Medicines, Inc.
InventorsSteven G. BALLMER, Xiaojun HUANG, Shaoling LI
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to novel methods for preparing rapamycin analog compounds, as well as to related intermediates useful in such methods.
Claims35
A process for preparing a compound of formula (3), or a salt thereof, comprising:
- (1a) contacting a compound of formula (1), or a salt thereof,
- with a reducing agent, to yield a compound of formula (2), or a salt thereof,
- (2a) contacting a compound of formula (2), or a salt thereof, with an amino protecting group reagent to yield a compound of formula (3), or a salt thereof,
- wherein PGN1 is an amino protecting group.
1 more element
A process for preparing a compound of formula (21), or a salt thereof, comprising:
- (1b) contacting a compound of formula (20), or a salt thereof,
- with a hydroxyl protecting group reagent, to yield a compound of formula (21), or a salt thereof,
- wherein PGO1 and PGO2 are the same or different at each instance a hydroxyl protecting group, optionally wherein step (1b) is performed in the presence of imidazole, and/or wherein step (1b) is performed in DCM.
A process for preparing a compound of formula (31), or a salt thereof, comprising:
- (1c) contacting a compound of formula (30), or a salt thereof,
- with a compound of formula (13), or a salt thereof,
- to yield the compound of formula (31), or a salt thereof,
- optionally wherein the process further comprises isolating the compound of formula (31).
1 more element
A compound of:
- (a) formula (13), or a salt thereof,
- (b) formula (13a),
- wherein x is 1, 2, or 3;
- (c) formula (13c),
- wherein y is 1, 2, or 3;
- or
- (d) formula (32), or a salt thereof,
4 more elements
Dependencies are inferred from the claim text.