Iodine labeled hydrogels and crosslinking agents for forming the same
AssigneeBoston Scientific Scimed, Inc.
InventorYen-Hao Hsu
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Abstract
In some embodiments, the present disclosure provides iodinated polyamino compounds having a plurality of primary amine groups, all of which are the same, as well as methods for forming the same. In some embodiments, the present disclosure pertains to systems for forming hydrogels, which systems comprise such an iodinated polyamino compound and a polymer that that forms crosslinks with the iodinated polyamino compound. In some embodiments, the present disclosure pertains to hydrogels that are formed using such systems.
Claims20
A system for forming a hydrogel that comprises an iodinated polyamino compound having a plurality of primary amine groups, all of which are identical, and a polymer that that forms crosslinks with the iodinated polyamino compound.
A method of treatment comprising administering to a subject a mixture that comprises an iodinated polyamino compound having a plurality of primary amine groups, all of which are identical, and a polymer that forms crosslinks with the iodinated polyamino compound under conditions such that the iodinated polyamino compound and the polymer crosslink after administration.
A method of forming an iodinated polyamino compound comprising (a) forming a partially protected polyamino compound by protecting all but one primary amine group of a polyamino precursor compound comprising three or more primary amine groups, (b) forming an amide linkage between a remaining unprotected primary amine group of the partially protected polyamino compound and a carboxyl group of a carboxylated iodinated precursor compound, and (c) deprotecting primary groups of the product of step (b).
Dependencies are inferred from the claim text.