Nanotherapeutics for treatment of sars-cov-2
AssigneeOregon State University
InventorsJeonghwan KIM, Anindit MUKHERJEE, Gaurav SAHAY
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Abstract
Embodiments provide for therapeutic agents and methods of use thereof, for treating one or more diseases or conditions. In one example, the therapeutic agent is a lipid nanoparticle comprised of an ionizable lipid, a PEG lipid, a sterol, and a structural lipid, the lipid nanoparticle including one or more mRNA molecules encoding for a soluble form of human angiotensin-converting enzyme 2 and/or variations thereof. In this way, one or more signs or symptoms of Covid-19 may be treated via use of the therapeutic agent.
Claims26
A method of treating a patient suffering from a condition or disease, comprising:
- administering to the patient an effective amount of a therapeutic agent comprising one or more RNA molecules encapsulated by a lipid nanoparticle;
- wherein said treating of the patient reduces at least one or more signs or symptoms associated with the condition or disease.
A therapeutic agent for treating a patient suffering from a viral infection, comprising:
- a lipid nanoparticle comprised of each of an ionizable lipid, a PEG lipid, β-sitosterol, and a structural lipid;
- and
- one or more mRNA molecules encoding at least a portion of a soluble protein encapsulated within the lipid nanoparticle.
A method of treating a patient suffering from an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), comprising:
- administering to the patient an effective amount of a therapeutic agent comprising one or more mRNA molecules encoding at least a portion of a soluble form of human angiotensin-converting enzyme 2 (hACE2) encapsulated by a lipid nanoparticle, the lipid nanoparticle including an ionizable lipid, a PEG lipid, β-sitosterol, and a structural lipid;
- wherein said treating of the patient reduces at least one or more signs or symptoms associated with the infection.
Dependencies are inferred from the claim text.