Nanoparticles pre-functionalised using a self-assembled monolayer and method for preparing same
AssigneesCentre National De La Recherche Scientifique, Ecole Normale Superieure Paris-Saclay
InventorsClaude Nogues, Malcolm Buckle, Stéphanie Vial
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Abstract
The present invention pertains to the field of pre-functionalized nanoparticles (NPs). It relates more particularly to NPs pre-functionalized using a self-assembled monolayer (SAM) and also to NPs functionalized using biomolecules such that the NPs are stable in solution. These NPs may be used in numerous applications, especially as a diagnostic tool, for depleting a molecule of interest in a solution, and therapeutic tool.
Claims10
A nanoparticle comprising a metal surface pre-functionalized using a self-assembled protective monolayer formed by a matrix of molecules M of formula (1):
- HS(CH2)n (OCH2CH2)m OH in which:
- n represents the number of CH2, where 3≤n≤11;
- and
- m represents the number of ethylene glycol, where 1≤m≤12;
- the molecule bearing a thiol functional group at one of the ends, the other end being inert;
- and
- wherein the coverage rate of the monolayer is between 1.5% and 99%.
Dependencies are inferred from the claim text.