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US 2024/0173401 A1Published application
Compositions and Methods to Enhance Therapeutic Efficacy of Cancer Therapies
AssigneeWisconsin Alumni Research Foundation
InventorsZachary S. Morris, Justin C. Jagodinsky
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Abstract
This disclosure relates to compositions and methods to enhance therapeutic efficacy of cancer therapies.
Claims26
A method of treating cancer in a subject in need thereof, comprising:
- a) administering a therapeutically effective amount of an adjuvant to a tumor of the subject, wherein the adjuvant is administered intratumorally;
- b) administering a therapeutically effective amount of a radiotherapy and/or local ablative therapy to the tumor;
- c) administering a therapeutically effective amount of an immune checkpoint inhibitor to the subject;
- and
- d) inducing an immune response to the cancer.
2 more elements
A composition for treating cancer, comprising:
- a) a therapeutically effective amount of an adjuvant;
- b) a therapeutically effective amount of an immune checkpoint inhibitor;
- and
- c) a pharmaceutically acceptable carrier or diluent.
1 more element
A method of treating cancer in a subject in need thereof, comprising:
- a) administering a therapeutically effective amount of a TLR4 agonist to a tumor of the subject, wherein the TLR4 agonist is administered intratumorally;
- b) administering a therapeutically effective amount of EBRT to the tumor;
- c) administering a therapeutically effective amount of an anti-CTLA-4 antibody to the subject;
- and
- d) at least one of reducing tumor volume, increasing overall survival of the subject, and increasing complete response rate in the subject.
2 more elements
(canceled)
Dependencies are inferred from the claim text.