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US 2024/0173391 A1Published application
Therapeutic combination for treating cancer
AssigneeNykode Therapeutics ASA
InventorsAgnete Øvre Fredriksen, Karoline Schjetne, Stine Granum, Audun Trygge Haugen Bersaas, Ina Park Rhee, Siri Brinchmann-Hansen Torhaug
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Abstract
This invention relates to methods and kits for treating a subject having cancer, e.g. a patient, by administering to the subject an anticancer vaccine in combination with one or more checkpoint inhibitors.
Claims47
A method for treating a subject having cancer, the method comprising administering to the subject
- (a) an anticancer vaccine comprising
- (i) a polynucleotide comprising a nucleotide sequence encoding a targeting unit that targets antigen-presenting cells, a multimerization unit, such as a dimerization unit, and an antigenic unit comprising one or more cancer antigens or parts thereof, or
- (ii) a polypeptide encoded by the polynucleotide as defined in (i);
- or
- (iii) a multimeric protein, such as a dimeric protein, consisting of multiple polypeptides as defined in (ii), such as of two polypeptides;
- and
- (b) one or more checkpoint inhibitors.
4 more elements
A kit comprising
- (a) an anticancer vaccine comprised in one or more first containers, wherein the anticancer vaccine comprises
- (i) a polynucleotide comprising a nucleotide sequence encoding a targeting unit that targets antigen-presenting cells, a multimerization unit, such as a dimerization unit, and an antigenic unit comprising one or more cancer antigens or parts thereof;
- or
- (ii) a polypeptide encoded by the polynucleotide as defined in (i);
- or
- (iii) a multimeric protein, such as a dimeric protein, consisting of multiple polypeptides as defined in (ii), such as of two polypeptides;
- and
- (b) one or more checkpoint inhibitors comprised in one or more second containers.
5 more elements
Dependencies are inferred from the claim text.