Compositions comprising relaxin and methods of use thereof
AssigneesBeth Israel Deaconess Medical Center, Inc., Trustees of Boston University
InventorsAra Nazarian, Edward K. Rodriguez, Mark Grinstaff
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Abstract
The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered intra-articularly as a sustained release formulation. The present invention also provides sustained release formulations in the form of a hydrogel for administering polypeptides that are covalently attached to a polymer, e.g., PEG.
Claims21
1-44. (canceled)
A sustained release formulation for delivering a polypeptide therapeutic or diagnostic agent covalently attached to a polymer, wherein:
- the formulation is a hydrogel comprising a polypeptide therapeutic or diagnostic agent covalently attached to a cross-linker comprising a polymer and a cleavable linker;
- and
- wherein the formulation releases the polypeptide therapeutic or diagnostic agent covalently attached to the polymer after the cleavable linker is cleaved chemically or enzymatically.
64-69. (canceled)
Dependencies are inferred from the claim text.