Compositions and methods for treating neurological and other disorders
AssigneeRush University Medical Center
InventorKalipada Pahan
Life of this patent
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Abstract
Methods for treating neurological and other disorders, including autoimmune disorders are described. Also described is a method of treating a disorder in which Toll-like Receptor 2 (TLR2) activation by binding to myeloid differentiation primary response 88 (MyD88) plays a role in disease pathogenesis. Further a method is described that includes the administration of a composition, including a peptide sequence, that inhibits the activation of TLR2 by MyD88.
Claims11
A method for treating a disorder in a patent, the method comprising administering to the patient in need of such treatment a therapeutically effective amount of a composition comprising a peptide comprising a Toll-like Receptor 2 (TLR2)-interacting domain of myeloid differentiation primary response 88 (MyD88), wherein the TLR2-interacting domain of MyD88 comprises the sequence PGAHQK (SEQ ID NO:
- 1), wherein the therapeutically effective amount is an amount that at least reduces TLR2-MyD88 signaling and wherein the disorder is selected from the group consisting of multiple sclerosis and rheumatoid arthritis.
-3. (canceled)
The method of claim 2, wherein the Antennapedia homeodomain is linked by the C-terminal of the Antennapedia homeodomain to the N-terminal of the sequence PGAHOK (SEQ ID NO:
- 1).
-11. (canceled)
(canceled)
-23. (canceled)
Dependencies are inferred from the claim text.