Liposomal formulations of boronic acid containing active agents

A liposomal formulation comprising:

• (i) liposomes formed from a vesicle-forming lipid;
• and
• (ii) a capturing agent-active agent complex encapsulated in the liposomes;
• wherein the capturing agent-active agent complex is a compound defined by Formula I:
• wherein
• P1 is hydrogen or an amino-group protecting moiety;
• R0 is hydrogen or an alkyl group;
• R1, R2, and R3 are independently hydrogen, an alkyl group, a cycloalkyl group, a heterocyclyl group, an aryl group, a heteroaryl group, an alkoxy, or —CH2—R4;
• R4 is an aryl group, an alkylaryl group, an arylalkyl group, a cycloalkyl group, an alkylcycloalkyl group, a heterocyclyl group, an alkylheterocyclyl group, a heteroaryl group, an alkylheteroaryl group, an alkoxy group, or an alkylthio group;
• m is 0, 1, or 2;
• and
• Z, together with O1 and O2, represent a capture agent, wherein Z comprises one or more charged moieties;
• or a pharmaceutically acceptable salt thereof.