Controlled release of bacteriophage to treat implant infections
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsOvijit CHAUDHURI, Paul L. BOLLYKY, Robert MANASHEROB, Yung-Hao LIN, Derek AMANATULLAH
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Abstract
Provided herein are hydrogels that include a plurality of bacteriophages located within and covalently bonded to the hydrogel interior. The hydrogel is engineered to facilitate a controlled sustained release of the connected bacteriophages, e.g., to or within the body of a patient suffering from a bacterial infection. Also provided are methods for forming the provided hydrogels, and for using the hydrogels to treat a patient suffering from a bacterial infection.
Claims24
A hydrogel comprising a plurality of bacteriophages located within the interior of the hydrogel, the hydrogel formed from one or more biopolymers, wherein each of at least a portion of the bacteriophages is connected to the hydrogel via one or more covalent bonds, and wherein the hydrogel is engineered to facilitate a sustained release of the connected bacteriophages.
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A method of forming a hydrogel comprising a plurality of bacteriophages located within the interior of the hydrogel, the method comprising:
- selecting a biopolymer;
- contacting the biopolymer with a linking agent under conditions suitable for forming the hydrogel;
- and
- contacting the hydrogel with the plurality of bacteriophages under conditions suitable for binding at least a portion of the bacteriophages to the interior of the hydrogel.
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Dependencies are inferred from the claim text.