Compositions and methods for treating cholestatic disease
AssigneeSeres Therapeutics, Inc.
InventorsMadhumitha NANDAKUMAR, Alice Peiyu LIOU, Elizabeth Moritz HALVORSEN, Gregory MCKENZIE, Edward J. O'BRIEN, David COOK
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Abstract
The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.
Claims24
A formulation comprising (i) a plurality of viable bacteria, which comprises at least one bacterial OTU or species that is capable of exhibiting a bile acid or bile salt metabolizing activity, and (ii) a pharmaceutically acceptable excipient.
-15. (canceled)
A method of treating a cholestatic disease or condition in a subject in need thereof, comprising administering to the subject a composition, which comprises at least one bacterial OTU or species that is capable of (i) deconjugating a primary bile acid or bile salt, (ii) metabolizing a primary bile acid or salt into a secondary bile acid, or (iii) both.
-18. (canceled)
-30. (canceled)
A method for identifying a bacterial species for use in a composition for altering bile acid metabolism in a subject, the method comprising comparing protein coding sequences of a bacterial strain to reference sequences in a database of proteins that catalyze a desired bile acid activity, wherein identification of a bacterial strain comprising a sequence with homology to a reference sequence indicates the identification of a bacterial strain for use in said composition.
-33. (canceled)
Dependencies are inferred from the claim text.