Methods, compositions, and systems for treating dental caries and a periodontal disease based on microbiome modulation through oral microbiome transplant (omt)

Abstract

Provided herein are methods, compositions, and systems for treating dental caries and a periodontal disease based on microbiome modulation through oral microbiome transplant (OMT). The original oral microbial composition was obtained from the dental plaque of healthy donors, and then modulated by growing a biofilm in vitro in a growth medium. The modulated oral microbial composition has a different microbial diversity than the original oral microbial composition. In the modulated oral microbial compositions, the abundance of some bacterial species changes, some new bacterial species are present, and some original bacterial species are no longer present. The modulated oral microbial composition is transplanted to the recipient's oral cavities through OMT to treat dental caries or a periodontal disease.

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