Compositions and methods for treating epilepsy and related disorders
AssigneeFinch Therapeutics Holdings LLC
InventorThomas Julius Borody
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Abstract
The present disclosure is in the field of pharmaceutical compositions suitable for the treatment of diseases in mammals. The disclosure provides novel compositions comprising non-pathogenic fecal microbes for treating epilepsy, epileptic seizures and related diseases. The disclosure also provides methods for treating a subject with the compositions disclosed herein.
Claims20
A method for treating epilepsy or seizure in a subject in need thereof, said method comprising orally administering to said subject a pharmaceutically active dose of a therapeutic composition comprising uncultured fecal bacteria.
A method of treating epilepsy or seizure in a subject in need thereof, said method comprising determining the relative abundance of one or more Akkermansia or Parabacteroides species in an intestine of the subject and orally administering to said subject a pharmaceutically active dose of a therapeutic composition comprising a non-selected fecal microbiota if the relative abundance of the one or more Akkermansia or Parabacteroides species is less than a threshold level.
A method of treating epilepsy or seizure in a subject in need thereof, said method comprising administering to said subject a pharmaceutically active dose of a therapeutic composition comprising uncultured fecal bacteria, wherein said subject is free of gut dysbiosis immediately prior to said treating.
Dependencies are inferred from the claim text.