Universal chimeric antigen receptor t-cell and application thereof
OwnerGuang HU, Jiayuan ZHANG +5inventors
InventorsGuang HU, Jiayuan ZHANG, Wenjing GAO, Wenjie DONG, Xiaomin YAO, Zhi LIU, Xiaoqian WANG
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Abstract
A cell comprising a mutant protein, the mutant protein causing the cell to be insensitive toward an inhibitor which affects the activity and; or killing function thereof; a universal chimeric antigen receptor T cell which is related to the cell and which is suitable for administration to non-specific patients; and a method for preparing the described cells and an application of the cells in cell therapy.
Claims34
1-13. (canceled)
A method for introducing T316 mutation into an Lck gene of a cell, comprising introducing a base editor, wherein the base editor is an ABE or CBE base editor.
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A cell expressing a chimeric antigen receptor, wherein the cell has cytotoxicity or is induced to have cytotoxicity, and the cell is engineered so that its cytotoxicity is insensitive to a cell activity inhibitor, wherein at least one bioactive molecule in the cell is engineered to be insensitive to the cell activity inhibitor, and the bioactive molecule can be inhibited by the cell activity inhibitor in a normal T cell.
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Dependencies are inferred from the claim text.