Treating Alagille Syndrome (ALGS)
OwnerJan Mattsson, Pat Horninventors
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Abstract
Provided herein are methods for Alagille syndrome (ALGS) with an ileal bile acid transport (IBAT) inhibitor such as odevixibat, or a pharmaceutically acceptable salt thereof. Such methods can include reducing pruritus score, serum bile acid concentration, increasing height, normalizing weight, improving sleep, and improving liver parameters.
Claims30
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A method for treating pruritus associated with Alagille Syndrome (ALGS) in a subject in need thereof, the method comprising orally administering to the subject a therapeutically effective amount of a pharmaceutical formulation comprising odevixibat, or a pharmaceutically acceptable salt thereof, wherein the subject exhibits a reduction in pruritus score relative to baseline following administration of the pharmaceutical formulation for at least 8 weeks.
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Dependencies are inferred from the claim text.