Combinatory therapy for preventing, inhibiting, treating, or reducing aneurysms
AssigneeThe Regents of the University of California
InventorHua Cai
Life of this patent
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Abstract
The present disclosure relates to pharmaceutical compositions comprising a folate compound and a calcium channel blocker, as well as the method for using such pharmaceutical compositions in the treatment of aneurysms.
Claims92
A kit comprising a folate compound and a calcium channel blocker.
The kit of any one of claims 11-33, wherein R8 is hydrogen, hydroxyl, alkoxy, alkylthio, alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl.
A method of preventing or treating aneurysms, comprising conjointly administering a folate compound and a calcium channel blocker to a subject in need thereof.
A method of ameliorating a symptom of an aneurysm, comprising conjointly administering a folate compound and a calcium channel blocker to a subject in need thereof.
A method of decreasing superoxide production, eNOS uncoupling activity, enlargement of blood vessels (abdominal aortas, thoracic aortas or blood vessels in the brain), vascular remodeling, elastin degradation (flattening and breakdown), vascular inflammation/macrophage infiltration, matrix metalloproteinase (MMP) activation, and/or adventitial hypertrophy in a subject afflicted with an aneurysm, comprising conjointly administering a folate compound and a calcium channel blocker to a subject in need thereof.
A method of increasing eNOS function, nitric oxide (NO), and tetrahydrobiopterin bioavailabilities in a subject afflicted with an aneurysm, the method comprising conjointly administering a folate compound and a calcium channel blocker to a subject in need thereof.
Dependencies are inferred from the claim text.