Composition for pharmaceutical tablet, pharmaceutical tablet using the same, and manufacturing method thereof

Abstract

The present invention provides a composition for a sustained-release tablet having such a high hardness to have chewing difficulty, and suppressing release of the pharmaceutical ingredient within a few hours after administration, but being able to release 90% or more of the pharmaceutical ingredient 10 hours after administration. The present invention also provides a tablet using the composition and a method for producing the tablet. The composition comprises a polyvinyl alcohol-based resin and crystalline cellulose, the polyvinyl alcohol-base resin having an average particle size of 100 μm or less and a viscosity of more than 44 mPa·s in 4% aqueous solution. The average particle size of the crystalline cellulose is preferably 250 μm or less, and either not greater than 0.5 times or not less than twice the size of the average particle size of the polyvinyl alcohol-based resin.

Dependencies are inferred from the claim text.