Anti-varicella-zoster virus antibody and use thereof
AssigneesBeijing Wisdomab Biotechnology Co., Ltd, Genrix (Shanghai) Biopharmaceutical Co. Ltd., Chongqing Genrix Biopharmaceutical Co., Ltd.
InventorsXueping ZHANG, Zhigang LIU, Xiaowei ZHOU, Xiaobo HAO, Junjie HU, Yulan LIU
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Abstract
Provided are an antibody against varicella-zoster virus, a nucleic acid molecule encoding the antibody, an expression vector comprising the nucleic acid molecule, a host cell comprising the nucleic acid molecule or the vector, a method for preparing and purifying the antibody, and the use of the antibody.
Claims18
-12. (canceled)
An antibody against varicella-zoster virus comprising a heavy chain variable region comprising the amino acid sequences of HCDR1, HCDR2 and HCDR3 and a light chain variable region comprising the amino acid sequences of LCDR1, LCDR2 and LCDR3, wherein
- the amino acid sequence of HCDR1 is TYAMH (SEQ ID NO:45), the amino acid sequence of HCDR2 is VISYGGGNRYYAASVKG (SEQ ID NO:46), the amino acid sequence of HCDR3 is ARDNHYFFGMDV (SEQ ID NO:47), the amino acid sequence of LCDR1 is RASQGISSWLA (SEQ ID NO:48), the amino acid sequence of LCDR2 is AASSLQS (SEQ ID NO:49), and the amino acid sequence of LCDR3 is QEGFYFPIN (SEQ ID NO:51);
- or
- the amino acid sequence of HCDR1 is SGNYWN (SEQ ID NO:29), the amino acid sequence of HCDR2 is YISYDGSTYYNPSLKN (SEQ ID NO:30), the amino acid sequence of HCDR3 is GYYGYWFAY (SEQ ID NO:31), the amino acid sequence of LCDR1 is RASSSVSYMH (SEQ ID NO:32), the amino acid sequence of LCDR2 is ATSNLAS (SEQ ID NO:33), and the amino acid sequence of LCDR3 is QQWSSNPFT (SEQ ID NO:34);
- or
- the amino acid sequence of HCDR1 is SGYYWN (SEQ ID NO:54), the amino acid sequence of HCDR2 is YISYDGSNNYNTSLKN (SEQ ID NO:55), the amino acid sequence of HCDR3 is EDVNYPPYALDY (SEQ ID NO:35), the amino acid sequence of LCDR1 is RSSQSLVHSNGNTYLH (SEQ ID NO:36), the amino acid sequence of LCDR2 is KVSNRFS (SEQ ID NO:37), and the amino acid sequence of LCDR3 is SQSTHVPWT (SEQ ID NO:38);
- or
- the amino acid sequence of HCDR1 is SYTMS (SEQ ID NO:39), the amino acid sequence of HCDR2 is FISNGGDNNYYADTVKG (SEQ ID NO:40), the amino acid sequence of HCDR3 is HNGNWGFAY (SEQ ID NO:41), the amino acid sequence of LCDR1 is SASSSISSNYLH (SEQ ID NO:42), the amino acid sequence of LCDR2 is RTSNLAS (SEQ ID NO:43), and the amino acid sequence of LCDR3 is QQGSSIPLT (SEQ ID NO:44);
- or
- the amino acid sequence of HCDR1 is TYAMH (SEQ ID NO:45), the amino acid sequence of HCDR2 is VISYGGGNRYYAASVKG (SEQ ID NO:46), the amino acid sequence of HCDR3 is ARDNHYFFGMDV (SEQ ID NO:47), the amino acid sequence of LCDR1 is RASQGISSWLA (SEQ ID NO:48), the amino acid sequence of LCDR2 is AASSLQS (SEQ ID NO:49), and the amino acid sequence of LCDR3 is QQANSFPLT (SEQ ID NO:50), QQATYFPIN (SEQ ID NO:52) or QQSSYFPIA (SEQ ID NO:53);
- wherein the amino acid sequences of HCDRs and LCDRs are defined according to Kabat.
Dependencies are inferred from the claim text.