Method for grafting surface of medical device by using quaternized trimethylamine
AssigneeVasular Interface Inc.
InventorsDo Yeon KIM, Jong Hee KANG, Su Gyung HAN
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Abstract
The present invention relates to a method for grafting a surface of a medical device by using quaternized trimethylamine. A catheter onto which quaternized trimethylamine has been grafted allows for the reduction of thrombus production. Therefore, the catheter having quaternized trimethylamine grafted thereto exhibits the effect of repressing thrombus production and enhancing the function of inhibiting blood adsorption and blood cell adsorption.
Claims13
A method of grafting quaternized trimethylamine on a surface of a substrate, comprising:
- mixing a reaction solvent, a catalyst, an initiator, and a compound having an isocyanate group with a substrate, followed by stirring, to modify the surface of the substrate;
- further mixing the surface-modified substrate with a reducing agent and a trimethylamine-based compound, followed by reacting, to form a trimethylamine polymer layer on the surface of the substrate;
- and
- further mixing the substrate with hydrogen peroxide or meta-chloroperoxybenzoic acid, followed by reacting, to form a quaternized trimethylamine graft polymer layer on the surface of the substrate.
A method of grafting quaternized trimethylamine on a surface of a substrate, comprising:
- introducing a hydroxyl group (—OH) into the surface of the substrate;
- further mixing the hydroxyl group-introduced substrate with an initiator, a reducing agent, and a trimethylamine-based compound, followed by reacting, to form a trimethylamine polymer layer on the surface of the substrate;
- and
- further mixing the substrate with hydrogen peroxide or meta-chloroperoxybenzoic acid, followed by reacting, to form a quaternized trimethylamine graft polymer layer on the surface of the substrate.
A method of grafting quaternized trimethylamine on a surface of a substrate, comprising:
- mixing a reaction solvent and an initiator with a substrate, followed by stirring, to modify the surface of the substrate;
- further mixing the surface-modified substrate with a reducing agent and a trimethylamine-based compound, followed by reacting, to form a trimethylamine polymer layer on the surface of the substrate;
- and
- further mixing the substrate with hydrogen peroxide or meta-chloroperoxybenzoic acid, followed by reacting, to form a quaternized trimethylamine graft polymer layer on the surface of the substrate.
Dependencies are inferred from the claim text.