Methods and kits for preparing radionuclide complexes
AssigneeTheragnostics Limited
InventorsPhilip Blower, Gregory Mullen
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Abstract
A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
Claims15
A method for obtaining a molecular image of a patient, said method comprising:
- a. having obtained or obtaining radiolabeled DKFZ-PSMA-11 at a temperature of 10 to 30° C. by adding a 0.1 M HCL gallium radioisotope eluate obtained directly from a gallium-68 radionuclide generator, without additional preparation, purification or concentration steps, to a lyophilized or freeze-dried chelator composition comprising:
- (i) a pharmaceutically acceptable buffer selected from a phosphate and an acetate buffer in an amount sufficient to increase the pH to a level in the range of 3 to 8;
- and
- (ii) DKFZ-PSMA-11;
- b. administering the radiolabeled DKFZ-PSMA-11 directly to a patient in need thereof;
- and
- c. obtaining a molecular image of a patient using a molecular imaging technique,
- wherein the lyophilized or freeze-dried chelator composition does not include agents inhibiting metals other than gallium.
A cold kit for direct radiolabeling of a biological targeting agent with Ga-68, the cold kit comprising:
- a lyophilized or freeze-dried chelator composition packaged in a single sterile sealed container, wherein the lyophilized or freeze-dried chelator composition does not include agents inhibiting metals other than gallium and comprises:
- a. a pharmaceutically acceptable buffer selected from a phosphate and an acetate buffer in an amount sufficient to increase the pH to a level in the range of 3 to 8 and
- b. DKFZ-PSMA-11.
Dependencies are inferred from the claim text.