US 2024/0165207 A1Published application

Composition for preventing or treating cancer comprising dual expressionvector for simultaneously expressing protein present in cell and protein secreted out of cell

AssigneesYd Life Science Co., Ltd, Korea Research Institute of Bioscience and Biotechnology

InventorsIncheol RYU, Daeun JEONG, Sihyeon AN, Seong Heon KIM, Yunseon KIM, Kanghyun RYOO, Hyunseung LEE, Dong-Oh YOON, Myoungwoo LEE, Misun WON, Joo-Young IM

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Abstract

The present invention relates to a composition for preventing or treating cancer, comprising a dual expression vector, and more specifically, to a method for effectively treating cancer by simultaneously inducing the actions of cancer metabolism drugs and cancer immunotherapy drugs by using a dual expression vector for simultaneously expressing an HIF-1α inhibitor and anticancer cytokines.

Claims10

Dependent claims

A method of preventing or treating cancer, the method comprising:

administering a composition comprising, as an active ingredient, a recombinant vector comprising a polynucleotide encoding a hypoxia-inducible factor-1α inhibitor, a polynucleotide encoding a 2A peptide, and a polynucleotide encoding an anticancer cytokine to a subject in need thereof.

Dependencies are inferred from the claim text.

Facts

Application: 18/283,589Filed 25 Mar 2022
Priority: KR 10-2021-003957526 Mar 2021
Published: 23 May 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification29 codes

A61K 38/44
Enzymes; Proenzymes; Derivatives thereof: oxidoreductases
A23L 33/18
Amino acids, peptides or proteins: peptides; Protein hydrolysates
A61K 38/02
Medicinal preparations containing peptides: peptides of undefined number of amino acids; Derivatives thereof
A61K 38/16
Medicinal preparations containing peptides: peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof